Ozempic, Wegovy, and Mounjaro have taken the weight loss world by storm, helping millions of people shed stubborn pounds, improve blood sugar levels, and lower the risk of chronic diseases. But as effective as these medications are, they come with some side effects that make it tough for many to stick with them.

Paul Curran, MPharm, a clinical pharmacist at Optimal You in the UK, explains that one specific side effect is prompting some users to stop the medication altogether. However, with proper management of this symptom, it’s possible to continue using these weight loss drugs safely and effectively to achieve their benefits.

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One particular side effect is driving people to stop using these weight loss injections: gastrointestinal (GI) distress. Nausea, vomiting, diarrhea, and constipation are common complaints, particularly when doses are increased too quickly. These GLP-1 receptor agonists mimic a hormone that regulates hunger and blood sugar, but they also slow digestion, causing uncomfortable GI issues for some patients.

A report found that 25,000 Americans were admitted to emergency rooms due to GI complications related to weight-loss drugs. So, what’s behind this? According to Paul Curran, MPharm, a clinical pharmacist with Optimal You in the UK, many patients rush to higher doses to see quicker results. However, this accelerates the side effects. It’s important to follow the recommended titration schedule, starting with lower doses and gradually increasing to give the body time to adjust.

Beyond GI issues, other side effects can make users give up on the drugs, such as:

• Fatigue and low energy, especially in the early stages

• Feeling full too quickly and bloating after small meals

• Gallbladder problems, including gallstones due to rapid weight loss

• Mood swings, such as anxiety or irritability

• Hair thinning, likely caused by quick weight loss rather than the medication itself

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How to Minimize GI Issues

Managing GI side effects is possible with a few simple strategies. Paul Curran suggests:

• Eating smaller, more frequent meals

• Staying hydrated

• Avoiding high-fat foods

It’s also important to maintain open communication with your doctor while taking these medications. Small adjustments in your diet or dosage can make all the difference. If the side effects persist, your doctor may recommend lowering the dosage or taking a break from the medication to allow your body to adjust.

While no two bodies respond the same, some users may tolerate Ozempic or Wegovy better than Mounjaro. So, it’s worth discussing both options with your doctor. Remember, these medications are powerful, but they’re not a quick fix. Success comes from following the prescribed schedule, staying in touch with your healthcare provider, and riding out those early bumps.